CalmZen

Evidence

Scientific References

The information on the CalmZen website is supported by published, peer-reviewed research. The studies below relate to the individual nutrients and to nerve health generally; they are provided for educational purposes and do not represent studies of the CalmZen product itself.

*Empzen is not endorsed by, sponsored by, or affiliated with any of these organizations.

  1. Peripheral neuropathy in people without diabetes. In a US Peripheral Neuropathy Research Registry, about 3 in 4 participants (847 of 1,112) had non-diabetic neuropathy. Davalos L, et al. Ann Clin Transl Neurol. 2025;12(7):1408–1417. doi:10.1002/acn3.70072 (Share among people already in a neuropathy registry, not the general population.)
  2. Oxidative stress and nerve cells. Nerve-cell (DRG) mitochondria are described as a source of reactive oxygen species. Leinninger GM, et al. Nat Clin Pract Neurol. 2006;2(11):620–628. doi:10.1038/ncpneuro0320
  3. Circulation and nerve health. In 2,057 people with type 2 diabetes, higher endothelin-1 (a vasoconstrictor) was associated with ~4× higher predicted risk of later peripheral neuropathy (HR 4.35; 95% CI 1.45–13.0). Pek SLT, et al. Eur J Endocrinol. 2020;182(4):429–438. doi:10.1530/EJE-19-0523 (Associated risk; wide confidence interval.)
  4. Magnesium. Magnesium acts as a physiological gatekeeper of the NMDA-receptor channel, central to nerve signaling. Srebro D, et al. Curr Med Chem. 2017;24(4):424–434. doi:10.2174/0929867323666161213101744
  5. Turmeric / Curcumin. A meta-analysis of 66 RCTs found lower inflammatory markers (CRP, TNF-α, IL-6) and improved antioxidant status. Dehzad MJ, et al. Cytokine. 2023;164:156144. doi:10.1016/j.cyto.2023.156144
  6. Acetyl-L-Carnitine (ALC). Two pooled 52-week RCTs (n=1,257) reported more regenerating nerve fibers and improved vibration perception. Sima AAF, et al. Diabetes Care. 2005;28(1):89–94. doi:10.2337/diacare.28.1.89
  7. Coenzyme Q10 (CoQ10). A 12-week placebo-controlled trial (n=49, 400 mg/day) reported lower neuropathy symptom scores and reduced lipid peroxidation. Hernández-Ojeda J, et al. J Diabetes Complications. 2012;26(4):352–358. doi:10.1016/j.jdiacomp.2012.04.004
  8. Alpha-Lipoic Acid (ALA). A meta-analysis of 4 RCTs (n=1,258) reported neuropathy symptom scores ~24% better than placebo (responders 52.7% vs 36.9%). Ziegler D, et al. Diabet Med. 2004;21(2):114–121. doi:10.1111/j.1464-5491.2004.01109.x (Intravenous ALA in diabetic patients — a clinical dose/route, not an oral supplement.)
  9. Nerve-pain medications. A clinical review reports average pain reduction of ~20–30%, with only about 1 in 5 to 1 in 3 patients reaching ≥50% relief — symptom relief only. Finnerup NB, Sindrup SH, Jensen TS. Handb Clin Neurol. 2013;115:279–290. doi:10.1016/B978-0-444-52902-2.00017-5
  10. Butcher's Broom (Ruscus). A meta-analysis of 10 RCTs (n=719) found a Ruscus-based combination eased leg heaviness and swelling and reduced leg volume. Kakkos SK, Allaert FA. Int Angiol. 2017;36(2):93–106. doi:10.23736/S0392-9590.17.03815-9 (Ruscus + hesperidin methyl chalcone + vitamin C, not Ruscus alone.)
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